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SUMMARY:LMB Seminar - How small molecules rescue a folding disease:  princ
 iples learned from the ion channel CFTR  - Jue Chen - Rockefeller Universi
 ty
DTSTART:20250407T140000Z
DTEND:20250407T150000Z
UID:TALK225718@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Cystic fibrosis is a genetic disorder caused by mutations in t
 he Cystic Fibrosis Transmembrane conductance Regulator (CFTR).  CFTR belon
 gs to the ATP-Binding Cassette (ABC) transporter family\, but uniquely fun
 ctions as an ion channel to regulate salt and fluid homeostasis. In this t
 alk\, I will discuss the molecular details of how CFTR functions\, the str
 uctural and functional defects caused by mutations\, and how drug molecule
 s act to revert these defects. 
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m link https://mrc-lmb-cam-ac-uk.zoom.us/j/93491001276?pwd=2utwaSIeA0haHVd
 OuRkZlBlQq6wzLb.1
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