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SUMMARY:Understanding and intercepting somatic clonal evolution in blood -
  George Vassiliou\, CSCI Cambridge
DTSTART:20250320T130000Z
DTEND:20250320T140000Z
UID:TALK226099@talks.cam.ac.uk
CONTACT:126982
DESCRIPTION:Each day humans produce more than 200 billion mature blood cel
 ls from 50\,000-200\,00 hematopoietic stem cells (HSCs). \nLike all somati
 c cells these long-lived HSCs inexorably acquire somatic mutations over ti
 me. \nMost mutations have no conspicuous consequences\, but a small minori
 ty impart their host HSC with a fitness advantage and drive it to expand c
 lonally.\nThis phenomenon\, known as clonal haematopoiesis (CH)\, becomes 
 ubiquitous with advancing age and is associated with an increased risk of 
 blood cancers\, as well as several non-haematological diseases.\nOver the 
 last few years\, we have been working to decipher the causes and consequen
 ces of CH\, with a particular focus on i) understanding the basis of clona
 l expansion\, ii) quantifying the risk of progression to blood cancer and 
 iii) developing approaches to prevent such progression.\nIn my talk\, I wi
 ll describe our progress with the hope of convincing you that we can make 
 blood cancer prevention a clinical reality in our lifetime.\n
LOCATION:CRUK CI Lecture Theatre
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