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SUMMARY:Detectability and cortical depth dependence of stimulus-driven hig
 h-frequency BOLD oscillations in the human primary somatosensory and motor
  cortex - Dr Shota Hodono\, Donders Center for Cognitive Neuroimaging\, Ni
 jmegen\, Netherlands.
DTSTART:20250127T123000Z
DTEND:20250127T133000Z
UID:TALK226186@talks.cam.ac.uk
CONTACT:Dace Apšvalka
DESCRIPTION:*Speaker:* Dr Shota Hodono\, Donders Center for Cognitive Neur
 oimaging\, Nijmegen\, Netherlands. \n\n*Title:* Detectability and cortical
  depth dependence of stimulus-driven high-frequency BOLD oscillations in t
 he human primary somatosensory and motor cortex.\n\n*Abstract:* In this ta
 lk\, I will present our work investigating the temporal specificity of Blo
 od Oxygen Level Dependent (BOLD) based fMRI\, in human primary somatosenso
 ry and motor cortex (https://doi.org/10.1162/imag_a_00427). Gradient recal
 led echo BOLD contrast allows inference of neuronal activity from associat
 ed hemodynamic changes. Consequently\, the local vascular architecture inf
 luences both the sensitivity and specificity of BOLD fMRI. The spatial spe
 cificity has been well studied. However\, the temporal aspects have been e
 xplored less. We studied the detectability of stimulus-driven high-frequen
 cy BOLD signal oscillations in M1 and S1 using cortical depth as a proxy f
 or the vascular hierarchy. We observed that\, at stimulation frequencies a
 bove 0.33 Hz\, the relative contribution of larger draining veins near the
  pial surface was significantly attenuated. This suggests that\, in additi
 on to low spatial specificity\, large draining veins may also exhibit redu
 ced temporal specificity. In this method-focused seminar\, I will also div
 e into the details of the experimental protocols\, the rationale of the sc
 an parameters\, our distortion-matched T1-EPI anatomical imaging\, and str
 ategies used to analyze the data. \n\n*Bio:* Shota enrolled the Biomedical
  Engineering PhD program at the New York University school of medicine in 
 the Cloos group. After 1.5 years at NYU\, he transferred together with his
  PhD supervisor to the University of Queensland in Australia. During his P
 hD\, Shota focused on technological developments for UHF fMRI and investig
 ated temporal specificity of fMRI using GRE-BOLD\, diffusion fMRI\, and DI
 ANA. Currently\, he is working as a postdoctoral fellow at the Donders Cen
 ter for Cognitive Neuroimaging under the supervision of David Norris\, foc
 using on technological developments for in-vivo transcranial ultrasound (T
 US)-fMRI.\n\n*Venue:* MRC CBU West Wing Seminar Room and Zoom https://us02
 web.zoom.us/j/82385113580?pwd=RmxIUmphQW9Ud1JBby9nTDQzR0NRdz09 (Meeting ID
 : 823 8511 3580\; Passcode: 299077)
LOCATION: MRC-CBU\, 15 Chaucer Road\, Cambridge
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