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SUMMARY:The Double Hit Hypothesis and Hyperandrogenism: Unraveling Social 
 Cognition Impairments in Daughters of Women with PCOS - Juan Pablo Del Rio
 \, Universidad de los Andes at Santiago
DTSTART:20250115T113000Z
DTEND:20250115T123000Z
UID:TALK226195@talks.cam.ac.uk
CONTACT:Simon Braschi
DESCRIPTION:Polycystic Ovary Syndrome (PCOS) is the most prevalent endocri
 ne disorder affecting women\, characterized by hyperandrogenism and metabo
 lic disturbances. Daughters of women with PCOS  are exposed to elevated an
 drogen levels during two critical developmental windows: prenatal life and
  puberty.  This "double hit" may disrupt key brain networks\, particularly
  the prefrontal cortex and limbic system\, impairing social cognition and 
 increasing vulnerability to mental health issues. Using a translational ap
 proach\, this presentation will go through animal and human models that ex
 plore the impact of androgen exposure on behavior\, brain connectivity\, a
 nd gene expression. Our findings aim to reveal biomarkers and mechanisms d
 riving these effects\, paving the way for early identification and interve
 ntions for at-risk individuals.
LOCATION:https://us02web.zoom.us/j/87076030035?pwd=XUpJuh8jiR0mae1AhkV79qb
 g8MtlSM.1
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