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SUMMARY:The ups and downs of budding yeast's transport of glucose - Peter 
 Swain (University of Edinburgh)
DTSTART:20250227T130000Z
DTEND:20250227T140000Z
UID:TALK226282@talks.cam.ac.uk
CONTACT:Anand Srinivasan
DESCRIPTION:Glucose is many organisms' preferred carbon source\, and its t
 ransport is complex with budding yeast using at least seven different hexo
 se transporters. Here we address why cells might have so many. Using mathe
 matical modelling\, we argue that one role of budding yeast's glucose-sens
 ing network is to mitigate a rate-affinity tradeoff inherent to transport 
 by facilitated diffusion. By combining time-lapse microscopy with dynamica
 lly changing concentrations of glucose\, we demonstrate that the transport
 er genes are regulated by a push-pull system of repressors. As glucose ris
 es\, repression by one type of repressor is weakened\, or `pulled'\, and r
 epression by the other type is strengthened\, or `pushed'. In falling gluc
 ose\, cells reverse the push-pull. Through this transcriptional regulation
 \, the glucose-sensing network matches levels of transporters by their aff
 inity to current concentrations of glucose. Together our results underpin 
 how budding yeast excels at importing glucose\, living up to its name of S
 accharomyces\, or sugar fungus.
LOCATION:MR12\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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