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SUMMARY:Proline metabolism and the tumour microenvironment – essential l
 essons from a non-essential amino acid - Professor Daniel Tennant\, Univer
 sity of Birmingham\, UK
DTSTART:20250416T140000Z
DTEND:20250416T150000Z
UID:TALK226432@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Why do tumour cells synthesise non-essential amino acids when 
 they are readily available in the microenvironment? This is a question tha
 t has led much of our research over the past few years\, and brought us to
  study the metabolism of proline\, an amino acid whose synthesis is intert
 wined with cellular redox homeostasis. In this talk\, I will discuss how p
 roline synthesis is important for maintaining mitochondrial redox homeosta
 sis\, how this is perturbed by oncogenic mutation and a hostile tumour mic
 roenvironment.
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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