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SUMMARY:Using Cryo-EM to Understand Evolution - Edward Egelman 
DTSTART:20250429T110000Z
DTEND:20250429T120000Z
UID:TALK226468@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:Since the advent of DNA sequencing\, the main tool for underst
 anding evolution has been the analysis of DNA and the proteins encoded by 
 the DNA. With the revolution in resolution that occurred in cryo-EM ~ 10 y
 ears ago\, cryo-EM has now emerged as the main technique for determining t
 he atomic structure of proteins\, nucleoprotein complexes\, and macromolec
 ular assemblies. We have known for some time that sequences diverge more r
 apidly than structures\, and thus examining structures can give insights i
 nto evolutionary relations that cannot yet be deduced at the level of sequ
 ences. I will show\, using examples of bacterial and archaeal flagella\, b
 acterial and archaeal pili\, and archaeal viruses how very deep evolutiona
 ry relations may be deduced at the level of structures. Further\, I will s
 how how ubiquitous prokaryotic surface filaments\, pili and flagella\, hav
 e undergone a surprising divergence due to adaptations to very different e
 nvironments. It has been the ability of these structures to adapt that acc
 ounts for their ubiquity.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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