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SUMMARY:Post-transcriptional regulations via small molecules targeting RNA
 -binding proteins - Peng Wu
DTSTART:20250603T110000Z
DTEND:20250603T120000Z
UID:TALK226471@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:Dysregulation of protein–RNA interactions has been associate
 d with various human diseases\, while few chemical matters targeting RNA-b
 inding proteins (RBPs) or RNAs are available. In this context\, the Wu gro
 up investigates small-molecule-based strategies targeting protein–RNA in
 teraction and RNA-binding proteins to offer new chemotypes for the modulat
 ion of post-transcriptional regulations. The overall goal is to address th
 e unmet need to investigate the pervasive yet understudied protein–RNA i
 nteractions and the associated biological regulatory network\, as well as 
 to answer the daunting question regarding the tractability of targeting RN
 A-binding proteins with new chemical modalities of therapeutic potential. 
 For example\, the group has successfully established discovery pipelines f
 or the identification of small molecules that targeted disease-associated 
 RNA-binding proteins involved in RNA biogenesis (LIN28)\, RNA cleavage and
  decay (RNase L and IRE1)\, and RNA modification (METTL16 and YTHDF2). Fur
 thermore\, proximity-inducing bifunctional molecules were studied in the g
 roup as chemical probes to illustrate the regulatory mechanism of the comp
 lex protein–RNA network or as potential drug candidates for the developm
 ent of small-molecule-based therapeutics with new mechanisms of action. Th
 e talk will exemplify recent small-molecule discovery efforts from the gro
 up targeting such RNA-binding proteins.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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