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SUMMARY:Nucleic-Acid based therapeutics: how to use mechanistic informatio
 n to ensure &quot\;safe-by-design&quot\; - Prof Anne Willis
DTSTART:20250204T180000Z
DTEND:20250204T193000Z
UID:TALK227035@talks.cam.ac.uk
CONTACT:Zhang Xianghao Jeffrey
DESCRIPTION:Advanced nucleic-acid based therapeutics (NATs) e.g. antisense
  oligonucleotides (ASOs)\, siRNAs and modified in vitro transcribed mRNAs\
 , can provide promising treatments ranging from mRNAs vaccines against COV
 ID19 and cancers\, to therapeutic ASOs to treat life-limiting genetic diso
 rders. However\, each therapy presents its own unique safety assessment ch
 allenges and preclinical studies have identified a range of toxicities for
  ASOs and siRNAs that are now observed in clinical trials.  Understanding 
 how NATs interact with and impact on the cellular machinery is key to prev
 enting off-target effects and to improve the safety profiles of these new 
 medicine platforms and this research is particularly important as we progr
 ess from using these new agents to treat rare to common diseases.\n\nTalks
  are priced at £4 for non-Scientific Society members. Scientific Society 
 members will have free access to all our talks. Lifetime membership costs 
 £15 and gives free access to all talks\, members-only events and priority
  access to oversubscribed SciSoc events.
LOCATION:Pfizer Lecture Theatre\,  Department of Chemistry\, Lensfield Roa
 d
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