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SUMMARY:Engineering Bubbles for Targeted Imaging and Therapy - Prof Eleano
 r Stride ( University of Oxford )
DTSTART:20250220T160000Z
DTEND:20250220T170000Z
UID:TALK227119@talks.cam.ac.uk
CONTACT:Michael Boemo
DESCRIPTION:Despite extraordinary advances in the development of new drugs
  and biotechnology\, cancer continues to represent one of the leading caus
 es of death worldwide. In many cases the problem lies not with the drugs b
 ut rather the difficulty in successfully delivering them to the site of a 
 tumour. In healthy tissue there is a regular structure of blood vessels su
 pplying oxygen and nutrients to cells\, which divide and grow at a steady 
 rate. In cancerous tumours\, however\, cell division and growth is unregul
 ated\, leading to a chaotic vessel structure and regions of tissue with li
 ttle or no blood supply. Consequently\, when drugs are ingested or injecte
 d into the blood stream not all parts of the tumour are treated and there 
 is a high risk of recurrence. Compounding this\, in many tumours there is 
 a pressure gradient that resists uptake of drugs from the blood vessels so
  that only a very small fraction is actually delivered. The rest of the dr
 ug circulates and is eventually absorbed by healthy tissue\, often leading
  to intolerable side effects. The goal of the research being carried out i
 n the Oxford Institute of Biomedical Engineering (IBME) is to develop new 
 methods for delivering anti-cancer drugs that overcome these barriers. In 
 particular physical stimuli such as ultrasound and magnetic fields are bei
 ng used to localise the release and improve the distribution of drugs with
 in tumours using micro and nanoscopic bubbles as delivery vehicles. In thi
 s talk\, Eleanor Stride will present the new techniques that have been dev
 eloped used to fabricate and characterise these bubbles\; and how they are
  being applied for the treatment of cancer.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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