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SUMMARY:The mathematics and physics of wound healing  - Professor Tanniemo
 la Liverpool\, University of Bristol
DTSTART:20250307T160000Z
DTEND:20250307T170000Z
UID:TALK227221@talks.cam.ac.uk
CONTACT:Professor Grae Worster
DESCRIPTION:I will discuss some recent work looking quantitatively at the 
 process of wound healing using ideas from thermodynamics\, continuum  and 
 statistical mechanics. Wound healing is a highly conserved process require
 d for survival of an animal after tissue damage. The wound repair process 
 is not only of great interest in its own right but is also a laboratory to
  study complex tissue dynamics and regeneration.\n\nMany wounds involve da
 mage to an epithelial (barrier) tissue (like skin) that separates differen
 t regions of the body of a living organism. I will describe some recent wo
 rk on studying wound healing in two dimensional epithelial tissues of a fr
 uit fly pupal wing. This epithelium was chosen because it is transparent a
 nd accessible to sophisticated imaging techniques. We use live confocal ti
 me-lapse microscopy to follow the behaviour of cells in a tissue before an
 d after wounding.\n\nI will focus on three cell-behaviours that are genera
 lly accepted to contribute to wound re-epithelialisation: cell shape defor
 mation\, cell division\, and cell migration.\n\nI will describe how we are
  beginning to use a combination of mathematics\, physics and biology to di
 sentangle some of the organising principles behind the complex orchestrate
 d dynamics that lead to wound healing.\n\n
LOCATION:MR2
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