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SUMMARY:Quantitative Biology Seminar  - David Savage\, UC Berkeley
DTSTART:20250519T113000Z
DTEND:20250519T123000Z
UID:TALK227452@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Mapping the biochemical landscape of CO2 fixation\nThe sequenc
 e-function landscape of a protein is the connection of genotype and phenot
 ype at a molecular level. Although abstract\, this concept has many real-w
 orld applications. Mapping and predicting this space would improve our bas
 ic science understanding of macromolecular function in the cell\, clarify 
 the role of genetic variation in causing disease\, and lead to our ability
  to design new proteins with enhanced activity\, stability\, and specifici
 ty. The goal of our work is to develop experimental methods to systematica
 lly explore the mutational landscape of important enzymes such ribulose bi
 sphosphate carboxylase / oxygenase\, the principal CO2-fixing enzyme in th
 e biosphere. A related effort is to create new types of assays that yield 
 robust measurements of biochemical parameters\, rather than relative measu
 rements which are typically measured out of convenience. Our work thus see
 ks to couple this data\, mechanistic studies\, and machine learning tools 
 to develop state of the art methods for predicting and engineering protein
  function. 
LOCATION:CRUK CI Lecture Theatre
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