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SUMMARY:From Cell Migration to Macropinocytosis: How the Local Microenviro
 nment Regulates Cell Behaviour - Jörg Renkawitz\, LMU Munich
DTSTART:20250206T160000Z
DTEND:20250206T170000Z
UID:TALK227695@talks.cam.ac.uk
CONTACT:125275
DESCRIPTION:Cells in multicellular organisms are exposed to local tissue m
 icroenvironments with various chemical and physical properties. Increasing
  evidence shows that these microenvironmental properties are a key regulat
 or of cellular behavior by shaping their signaling cascades\, gene express
 ion\, and functionality. In the first part of the talk\, I will show novel
  discoveries on how the cellular microenvironment influences the integrity
  of intracellular organelles. In particular\, we identify that the centros
 ome is susceptible to mechanical forces during cellular navigation\, unrav
 el underlying protective molecular pathways\, and describe the detrimental
  consequences of centrosome breakage for the functionality of the microtub
 ule cytoskeleton and for the motility of immune cells.\nIn the second part
  of the talk\, I will present new findings on how the sampling of the micr
 oenvironment is regulated by the properties of the microenvironment. Using
  macrophages as a cellular model highly active in microenvironmental sampl
 ing by macropinocytosis\, we identified cellular adhesiveness to their loc
 al surrounding as an important regulator of macropinocytosis. Overall\, th
 ese new findings show important principles of cell-matrix interplay and cy
 toskeleton regulation.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology building\, Downing Site 
 CB2 3EG
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