BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Nuclear structural networks: The hardware for regulation of gene e
 xpression and stem cell fate - Harald Hermann\, German Cancer Research Cen
 tre (Deutsches Krebsforschungszentrum\, DKFZ)\, Heidelberg
DTSTART:20100122T140000Z
DTEND:20100122T150000Z
UID:TALK22826@talks.cam.ac.uk
CONTACT:Duncan Simpson
DESCRIPTION:Lamins are intermediate filament (IF) proteins specialized to 
 form two-dimensional networks at the inner nuclear membrane (INM) of every
  metazoan cell nucleus\, as impressively seen in the giant cell nuclei of 
 Xenopus laevis oocytes. The establishment of such regular and extended lam
 in fiber systems as well as their degree of connectivity is extensively re
 gulated by factors within the INM\, such as emerin and lamin B receptor (L
 BR). Thereby a structure is formed that has been called by  Blobel and col
 leagues “the nuclear lamina”. Moreover\, lamins coordinate interaction
 s that occur specifically in somatic cells\, i.e. the association of the n
 uclear envelope with components of interphase chromatin such as histones a
 nd the barrier-to-autointegration factor (BAF). Recently\, mutations in la
 min A have been demonstrated to cause a bewildering number of different hu
 man diseases such as Emery-Dreifuss muscular dystrophy (EDMD)\, cardiomyop
 athy and premature ageing. The various pathomechanisms may in part depend 
 on structural changes of the nuclear envelope\, however\, they may also re
 late to the specific association with distinct signalling molecules\, tran
 scription factors and chromosomes. In addition\, it has been hypothesized 
 that a widespread A-type lamin system may functionally organize architectu
 re within the cell nucleus. We have now established conditions to renature
  recombinant lamin A and generate homogenous complexes in order to analyze
  the potential interactions these molecules undertake to form fibrillar st
 ructures. Thereby we are also able to investigate at which level of organi
 zation wild-type and mutated lamin A molecules differ.\n\nHarald Herrmann\
 nGroup Functional Architecture of the Cell\nDivision Molecular Genetics\nG
 erman Cancer Research Center (DKFZ)\nHeidelberg\, Germany\n
LOCATION:Pippard Lecture Theatre\, Cavendish Laboratory\, Department of Ph
 ysics
END:VEVENT
END:VCALENDAR