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SUMMARY:“Neutrophils drive vascular occlusion\, pleomorphic tumour necro
 sis\, and metastasis” - Jose M. Adrover\, Francis Crick Institute
DTSTART:20250220T160000Z
DTEND:20250220T170000Z
UID:TALK228421@talks.cam.ac.uk
CONTACT:Ruth Paton
DESCRIPTION:We are delighted to welcome Jose M. Adrover\, The Francis Cric
 k Institute as the speaker for this week's Cambridge Immunology Network Se
 minar Series.\n\nTalk Title: “Neutrophils drive vascular occlusion\, ple
 omorphic tumour necrosis\, and metastasis”\n\nAbstract: Tumour necrosis 
 is associated with poor prognosis in cancer and is thought to occur passiv
 ely when tumour growth outpaces nutrient supply. We found\, however\, that
  neutrophils actively induce tumour necrosis. In multiple cancer mouse mod
 els\, we found a tumour-elicited Ly6GHigh Ly6CLow neutrophil population th
 at was unable to extravasate in response to inflammatory challenges but fo
 rmed neutrophil extracellular traps (NETs) more efficiently than classical
  Ly6GHigh Ly6CHigh neutrophils. The presence of these “vascular restrict
 ed” neutrophils correlated with the appearance of a “pleomorphic” ne
 crotic architecture in mice. In tumours with pleomorphic necrosis\, we fou
 nd intravascular aggregates of neutrophils and NETs that caused occlusion 
 of the tumour vasculature\, driving hypoxia and necrosis of downstream vas
 cular beds. Furthermore\, we found that cancer cells adjacent to these nec
 rotic regions (i.e.\, in “peri-necrotic” areas) underwent epithelial-t
 o-mesenchymal transition\, explaining the paradoxical metastasis-enhancing
  effect of tumour necrosis. Blocking NET formation genetically or pharmaco
 logically reduced the extent of tumour necrosis and lung metastasis. Thus\
 , by showing that NETs drive vascular occlusion\, pleomorphic necrosis\, a
 nd metastasis\, we critically demonstrate that tumour necrosis is not nece
 ssarily a passive byproduct of tumour growth and that it can be blocked to
  reduce metastatic spread.\n\nDate: Thursday\, 20 February 2025\n\nTime: 1
 6:00-17:00 GMT\n\nLocation: Ground Floor Lecture Theatre\, Jeffrey Cheah B
 iomedical Centre (JCBC)\n\nHost: Maike De La Roche\, Cancer Research UK Ca
 mbridge Institute\n\nWe encourage in-person attendance. However\, if you a
 re unable to join us\, please email enquiries@immunology for a Zoom link.\
 n\nRefreshments are provided following the seminar for attendees.\n\nThe s
 eminar series is a collaboration between the Cambridge Immunology Network 
 and supported by the Cambridge Institute of Translational Immunology and I
 nfectious Disease (CITIID).\n\nSeminars take place weekly on Thursdays at 
 4pm and feature a leading speaker from the immunology field.\n\nFor more i
 nformation please contact: enquiries@immunology.ac.uk
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bi
 omedical Campus
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