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SUMMARY:“Self-protection of the early embryo: a dynamic perspective on p
 hagocytosis in natural environments” - Dr Esteban Hoijman. Embryonic Cel
 l Bioimaging lab\, Molecular Biology Institute of Barcelona\, IBMB-CSIC/I
 DIBELL
DTSTART:20250306T160000Z
DTEND:20250306T170000Z
UID:TALK228799@talks.cam.ac.uk
CONTACT:125275
DESCRIPTION:Early embryogenesis is a highly plastic stage\, capable of ove
 rcoming a wide range of perturbations. Significant efforts have been dedic
 ated to understanding how pluripotent cells adapt their developmental prog
 rams in response to deviations. However\, how the embryo protects its cell
 s from these perturbations without possessing its own immune system remain
 s poorly understood. Our previous research revealed that epithelial cells 
 on the embryonic surface (trophectoderm in mammals) can eliminate apoptoti
 c cells through phagocytosis. Here\, I will present our latest findings de
 monstrating that the early embryo can also clear infectious agents. Using 
 a quantitative live imaging approach\, we investigate this process across 
 biological scales in zebrafish\, mouse\, and human embryos. Additionally\,
  our model serves as a platform to study the phagocytic dynamics of microo
 rganisms carried out by epithelial tissues in natural environments.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology building\, Downing Site 
 CB2 3EG
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