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SUMMARY:Incorporating Flexibility in Antibody-Antigen Interaction Predicti
 on - Sara Joubbi
DTSTART:20250226T173000Z
DTEND:20250226T180000Z
UID:TALK228874@talks.cam.ac.uk
CONTACT:Pietro Lio
DESCRIPTION:Antibodies are vital to our immune system\, recognizing specif
 ic antigens with high precision. This makes them promising for therapies a
 gainst infectious diseases. While potent monoclonal antibodies can be extr
 acted\, studying their binding remains costly and time-consuming. Integrat
 ing in-vitro and in-silico approaches accelerates development\, but many c
 omputational methods overlook the crucial role of flexibility in binding.\
 n\nIn this talk\, we will explore why flexibility is essential for predict
 ing antibody-antigen interactions and how it can be modeled using the pred
 icted Local Distance Difference Test (pLDDT) as a proxy within a fingerpri
 nt-based approach. We will conclude with a discussion on future directions
  and challenges in the field.\n\nGoogle Meet: https://meet.google.com/bij-
 bnwo-ije
LOCATION:Lecture Theatre 2\, Computer Laboratory\, William Gates Building
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