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SUMMARY:Interactions of Epidermal Growth Factor Receptor Inhibition with D
 NA damage in the treatment of gastrointestinal cancer - Prof Daniel Hochha
 user\, University College London
DTSTART:20100914T110000Z
DTEND:20100914T120000Z
UID:TALK22909@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:There has been extensive development of targeted therapies for
  treatment of cancer. These include antibodies and small molecules which i
 nhibit pathways essential for cancer cell proliferation and metastasis. An
  important example is the epidermal growth factor receptor (EGFR) pathway 
 which is the target of antibodies (cetuximab\, panitumumab) and small mole
 cules (gefitinib\, erlotinib) used clinically. Although specific EGFR muta
 tions found in lung cancer result in significant sensitivity to gefitinib 
 and erlotinib\, the response to single agents has been modest. Preclinical
  evaluation has suggested synergy between chemotherapy and radiation when 
 combined with EGFR inhibition. However this has not generally translated i
 nto clinical benefit. In this presentation the possible mechanisms of thes
 e interactions will be outlined\, together with suggestions for design of 
 optimal combinations of EGFR inhibitors and chemotherapy\, using gastroint
 estinal cancer as an example.
LOCATION:CRI Lecture Theatre
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