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SUMMARY:Deciphering EMT morphogenetic forces - Dr. Magali Suzanne. The Cen
 tre de Biologie Intégrative\, Toulouse\, France
DTSTART:20250320T160000Z
DTEND:20250320T170000Z
UID:TALK229366@talks.cam.ac.uk
CONTACT:125275
DESCRIPTION:Folding is a basic morphogenetic process essential to shape or
 gans and tissues. Apical constriction is often viewed as the main driving 
 force leading to epithelium folding. Consistent with other recent studies\
 , our work highlights the importance of apico-basal forces in epithelium f
 olding\, coming either from apoptotic cells or from cells undergoing epith
 elia-mesenchymal transition (EMT). We are further studying the force gener
 ation mechanism taking place during the initial steps of the EMT process\,
  leading to the detachment of the extruding cell.  We are also analyzing
  how the forces generated during EMT affect cell nucleus and whether and h
 ow they contribute to the transcriptional shift observed during this cellu
 lar process.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology building\, Downing Site 
 CB2 3EG
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