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SUMMARY:Eating and walking- how cancer cells balance their energy supply a
 nd demand - Lisa Dobson\, Osian Jones\, Roberta Palmulli\, Shatruhan Rajpu
 t
DTSTART:20250321T150000Z
DTEND:20250321T160000Z
UID:TALK229636@talks.cam.ac.uk
CONTACT:Daisy Saward
DESCRIPTION:Tumours can be hypoxic nutrient-poor environments that challen
 ge cell survival.  They also have imbalanced mechanical forces due to the 
 deposition of extracellular matrix and the breakdown of normal tissue arch
 itecture.  Cancer cells that show plasticity and adaptability have a survi
 val advantage in these harsh conditions.  Our group is interested in how c
 ancer cells adapt to these conditions.  We focus mainly on pancreatic canc
 er\, a cancer of unmet need that is highly metastatic.  Lisa will discuss 
 how cells use their creatine-phosphagen system to recycle ATP and thus boo
 st their energy supplies for invasive migration.  Osian will discuss how m
 itochondria can adapt to harsh tumour conditions and promote cell migratio
 n.  Roberta will introduce macropinocytosis\, an actin cytoskeleton-based 
 method for cells to take up nutrients in large gulps.  Finally\, Shatruhan
  will discuss how mechanosensing affects cell mechanical properties and ho
 w this correlates with cell migration.  In summary\, we will discuss how t
 he harsh tumour microenvironment drives adaptations in cells\, causing the
 m to subvert normal pathways to drive tumour aggressiveness.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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