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SUMMARY:DNA-Encoded Chemical Libraries - A BIOLOGICAL RIG SEMINAR - Profes
 sor Dario Neri - CEO and CSO of Philogen\, Professor of ETH Zürich\, Hono
 rary Senior Visiting Fellow\, Department of Radiology\, University of Camb
 ridge (UK)
DTSTART:20250331T140000Z
DTEND:20250331T150000Z
UID:TALK229726@talks.cam.ac.uk
CONTACT:Xani Thorman
DESCRIPTION:The discovery of small organic ligands\, capable of specific r
 ecognition of protein targets of interest\, is a central problem in Chemis
 try\, Pharmacy\, Biology and Medicine.\nTraditionally\, small organic liga
 nds to proteins are discovered by screening\, one by one\, individual comp
 ounds from chemical libraries. However\, the technology is cumbersome\, ve
 ry expensive and is typically limited to the testing of up to one million 
 compounds.\nDNA-encoded chemical library (DEL) technology allows the const
 ruction and screening of much larger compound libraries\, without the need
  for expensive instrumentations and logistics. DELs are collections of mol
 ecules\, individually coupled to distinctive DNA fragments\, serving as am
 plifiable identification barcodes. Binding compounds can be selected using
  affinity capture procedures\, with the protein target of interest immobil
 ised on magnetic beads. After this “fishing” experiment\, the DNA barc
 odes can be PCR amplified and quantified using high-throughput DNA sequenc
 ing [1].\nIn this lecture\, I will present theory and applications of DEL 
 technology. I will also show examples of DEL-derived ligands\, isolated in
  our laboratories\, which have been tested in patients with cancer\, with 
 promising clinical results.\n
LOCATION:Department of Chemistry\, Cambridge\, Pfizer LT
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