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SUMMARY:Mechanobiology-Inspired Antithrombotic Strategies and Point-of-Car
 e Microtechnologies - Professor Arnold Lining Ju\, University of Sydney
DTSTART:20250606T130000Z
DTEND:20250606T140000Z
UID:TALK229870@talks.cam.ac.uk
CONTACT:46601
DESCRIPTION:Cardiovascular diseases remain the leading cause of death glob
 ally\, with thrombosis playing a central role in their pathogenesis. Curre
 nt antithrombotic therapies\, while effective\, often carry significant bl
 eeding risks due to their inability to differentiate between pathological 
 and physiological blood clotting. This presentation introduces our integra
 ted approach that combines fundamental mechanobiology with translational e
 ngineering to address critical clinical needs in cardiovascular medicine\,
  potentially transforming how we diagnose\, monitor\, and treat thrombotic
  disorders.\n\nFirst\, using our single-cell biomechanical nanotools such 
 as Biomembrane Force Probe (BFP)\, we present insights into thrombosis mec
 hanobiology\, particularly focusing on the role of von Willebrand Factor (
 VWF) and other mechanoreceptors (GPIbα\, integrin αIIbβ3 and PIEZO1 ion
  channels) in distinguishing between "good" and "bad" mechanical forces in
  thrombosis. These helped uncover new therapeutic targets for force-sensit
 ive antithrombotic strategies. Second\, we demonstrate a personalized vess
 el-on-chip platform that recreates patient-specific blood vessel geometrie
 s and flow conditions\, enabling precise evaluation of thrombotic risk and
  drug responses. Finally\, we introduce novel point-of-care microtechnolog
 ies for rapid blood coagulation testing\, including an AI-powered platform
  called SmartClot\, which promises to revolutionize home-based coagulation
  monitoring. These innovations represent a significant\nadvancement toward
  more effective and safer antithrombotic treatments\, with potential appli
 cations ranging from preventive care to personalized medicine.\n\nProfesso
 r Lining Arnold Ju PhD GAICD FHEA\n\nSnow Fellow\, Australian Heart Founda
 tion Future Leader Fellow and Australian Academy of Science John Booker Me
 dal\, The University of Sydney\, School of Biomedical Engineering.\n\nDr. 
 Ju received his PhD in Biomedical Engineering at Georgia Institute of Tech
 nology and Emory University\, USA in 2013. From 2014 to 2019\, he joined t
 he Australian Centre for Blood Diseases\, Monash University\, Melbourne\, 
 then Heart Research Institute\, Sydney as an Australian Heart Foundation P
 ostdoc Fellow. In early 2020\, Dr. Ju became an independent PI at the Univ
 ersity of Sydney (USYD)’s new School of Biomedical Engineering and start
 ed up the Mechanobiology and Biomechanics Laboratory (MBL).\n\nDr. Ju work
 s at the biomedical engineering and mechanobiology. His team has pioneered
  multiple biomechanical nanotools\, including multi-parametric thrombus pr
 ofiling microfluidics (Nature Materials 2019\; Nature Communications 2024)
 \, patient-specific vessel-on-a-chip platform (Advanced Materials 2025\; S
 cience Advances 2025)\, single-cell biomembrane force probes (Nature Commu
 nications 2018)\, 4D hemodynamic modeling (Nature 2021\; Blood 2025) and f
 luorescent micropipette aspiration assays (Nature Communications 2024). Hi
 s novel understanding of the mechanics behind blood clot formation has pro
 found implications for diagnosing and preventing thrombosis in heart attac
 ks and strokes. His vision is to build novel platforms that integrate adva
 nced biomanufacturing\, high-throughput biomechanical phenotyping\, and ge
 nerative AI towards rapid and intelligent biosensing technologies for agin
 g\, diabetes\, obesity\, hypertension\, vaccine and autoimmune related thr
 ombotic risks.
LOCATION:Oatley 1 Meeting Room\, Department of Engineering
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