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SUMMARY:Induction\, persistence and function of microbiota-specific CD4 T 
 cell memory - Jakob Zimmermann\, Department for Biomedical Research\, Univ
 ersity of Berne
DTSTART:20250710T150000Z
DTEND:20250710T160000Z
UID:TALK230107@talks.cam.ac.uk
CONTACT:Ruth Paton
DESCRIPTION:This Cambridge Immunology Network Seminar will take place on T
 hursday 10 July 2025\, starting at 4:00-5:00pm\n\nSpeaker: Jakob Zimmerman
 n\, Department for Biomedical Research\, University of Berne\, Germany\n\n
 Title: "Induction\, persistence and function of microbiota-specific CD4 T 
 cell memory"\n\nAbstract: The intestinal microbiota contains a vast array 
 of antigens\, which throughout life stimulate mucosal T cell responses. To
  demonstrate how intermittent exposures to an intestinal symbiont drive an
 tigen-specific CD4 T cell resident memory\, we have genetically engineered
  a mutant strain of Lactobacillus reuteri that reversibly colonizes the gu
 t of germ-free mice. We have combined this system that uncouples microbial
  exposure from permanent colonization with detection of antigen-specific T
  cells by custom adoptive transfer and peptide:MHC tools to address the in
 duction\, persistence\, and function of microbiota-directed CD4 T cell res
 ponses. Our findings reveal that benign symbionts elicit long-lived\, anti
 gen-independent\, tissue-resident CD4 T cells with significant implication
 s for our understanding of host–microbial mutualism in the intestine.\n\
 nHost: Noe Rodriguez Rodriguez\, MRC Laboratory of Molecular Biology\n\nRe
 freshments will be available following the seminar.
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bi
 omedical Campus
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