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SUMMARY:Elucidating T Cell Signalling Dynamics Using Reconstitution and Op
 togenetics - Dr John James\, Warwick Medical School. Warwick Medical Schoo
 l
DTSTART:20250717T150000Z
DTEND:20250717T160000Z
UID:TALK230110@talks.cam.ac.uk
CONTACT:Ruth Paton
DESCRIPTION:This Cambridge Immunology Network Seminar will take place on T
 hursday 17 July 2025\, starting at 4:00pm\, in the Ground Floor Lecture Th
 eatre\, Jeffrey Cheah Biomedical Centre (JCBC)\n\nSpeaker: Dr John James\,
  Associate Professor\, Warwick Medical School\, University of Warwick\n\nT
 itle: Elucidating T Cell Signalling Dynamics Using Reconstitution and Opto
 genetics\n\nAbstract: T cells are an essential part of our immune system\;
  they detect infected cells and either directly kill or orchestrate their 
 removal to keep us healthy despite constant exposure to potential pathogen
 s. Great progress has been made in identifying the parts of the signalling
  networks that T cells use to execute these decision-making processes\, an
 d we now have near-complete lists of these pathways. However\, to fully de
 scribe T cell function we must also understand how signals traverse these 
 network connections\, but this knowledge remains far more limited in T cel
 ls.\n\nTo address this limitation\, we use cellular reconstitution and lig
 ht-mediated control over these signalling pathways to directly and quantit
 ively investigate T cell signalling in the cellular context. In the talk\,
  I will show how we have used these discovery-based tools to better unders
 tand the mechanisms of action for new therapeutics (bispecifics/CAR-T)\, a
 s well as preliminary data on quantifying inhibitory receptor function. I 
 will also present our reconstitution work on how the pre-T cell receptor c
 an drive commitment to the αβ-T cell lineage in the absence of ligand.\n
 \nHost: Maike De La Roche\, CRUK Cambridge\n\nRefreshments will be availab
 le following the seminar.
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bi
 omedical Campus
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