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SUMMARY:Cellular redox homeostasis and regulation in the cell proliferatio
 n in relation to stress tolerance - Christine H. Foyer\, Centre for Plant 
 Sciences\, Faculty of Biology\, University of Leeds
DTSTART:20100212T130000Z
DTEND:20100212T133000Z
UID:TALK23073@talks.cam.ac.uk
CONTACT:15560
DESCRIPTION:Cellular redox homeostasis is considered to play an important 
 role in the regulation of the plant cell cycle but there is little informa
 tion on the precise functions of key redox metabolites such as ascorbate\,
  glutathione and pyridine nucleotides in this process. In this seminar\, I
  will show how the intracellular redox state was modulated during the grow
 th cycle and discuss the interplay between the major redox pyridine nucleo
 tides\, glutathione and ascorbate pools (Pellny et al.\, 2009).  Evidence 
 of similarities in the redox control of cell proliferation in animals and 
 plants are provided\, particularly glutathione recruitment into the nucleu
 s early in the cell proliferation\, which appears to be important in the c
 ontrol of progression through the cell cycle in both kingdoms. GSH accumul
 ation in the nucleus is triggered in Arabidopsis cells in culture by treat
 ments that synchronize cells at G1/S as identified by flow cytometry and m
 arker transcripts. GSH recruitment into the nucleus has marked effects on 
 metabolism and signaling in the cytoplasm\, chloroplasts and nucleus. For 
 example\, a comparison of the GSH:nuc and GSH:cyt transcriptomes revealed 
 that significant decreases in transcripts associated with oxidative signal
 ing and stress tolerance occurred when GSH was localized in the nucleus. T
 he relationships between the intracellular glutathione pools\, poly (ADP-r
 ibose) polymerase (PARP) activities and the abundance of PARP1 and PARP2 m
 RNAs\, will be discussed in terms of the regulation of growth and defence.
 \n\nReference : Pellny TK\, Locato V\, Diaz Vivancos P\, Markovic J\,  De 
 Gara L et al.\, (2009) Pyridine nucleotide cycling and control of intracel
 lular redox state in relation to poly (ADP-ribose) polymerase activity and
  nuclear localisation of glutathione during exponential growth of Arabidop
 sis cells in culture. Molecular Plant 2: 442-456.\n
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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