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SUMMARY:Ana Patricia Ramos-Forming an Eye: from cell behaviour to tissue s
 hape changes\; Kumud Saini-Temperature Regulation of Cell Cycle and Growth
  Dynamics in Arabidopsis - Kumud Saini\, Robinson Lab\, Sainsbury Laborato
 ry &amp\; Ana Patricia Ramos\, IGC\, Portugal 
DTSTART:20250609T133000Z
DTEND:20250609T143000Z
UID:TALK230881@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Ana Patricia Ramos \n \nTitle:Forming an Eye: from cell behavi
 our to tissue shape changes \n\nAbstract: Building an organ is a multistep
  process in which correct morphogenesis arises from feedback loops between
  genetic regulation and mechanical forces. A key morphogenetic event is th
 e emergence of tissue curvature\, which is essential for various developme
 ntal processes\, such as gastrulation\, and shapes multiple organs\, inclu
 ding the heart and neural tube. \n\nCurvature can develop alongside other 
 cellular and tissue rearrangements. In many of these complex contexts\, th
 e biomechanical interactions driving curvature remain unclear\, as the con
 tributions of individual rearrangements and their interplay are difficult 
 to disentangle. \n\nTo address this\, we investigated the morphogenesis of
  the vertebrate optic cup\, a highly curved structure that forms from a fl
 at bilayered optic vesicle. Using zebrafish as a model system\, where cell
  and tissue dynamics can be studied in native 4D conditions\, we combined 
 in vivo experiments\, 4D segmentation and analysis\, and theoretical model
 ing. This interdisciplinary approach allowed us to identify key players dr
 iving the emergence of optic cup curvature. \n\nKumud Saini (Robinson Lab\
 , Sainsbury Laboratory) \n\nTittle: Temperature Regulation of Cell Cycle a
 nd Growth Dynamics in Arabidopsis   \n\nAbstract: Living organisms exhibit
  maximum growth when they are in optimal conditions. A plastic development
 al program allows organisms to sense environmental cues and express phenot
 ypes better fitting their environments. An increase in global temperature 
 has been shown to affect plant phenology\, including the timing of vegetat
 ive and reproductive growth. In Arabidopsis thaliana\, warm growth tempera
 tures promote cell elongation in the hypocotyl\, stems\, and petioles\, wh
 ich is predicted to aid in cooling and protecting meristems. In contrast\,
  warm temperature restricts leaf growth by inhibiting cell division and pr
 omoting cell expansion. To explain this contrasting effect on division and
  expansion and to explore the causal link between the two\, we combined li
 ve cell imaging with Atomic Force Microscopy (AFM) in young proliferating 
 leaves. Through cell-lineage tracking and imaging of cell cycle markers\, 
 we propose that elevated temperatures affect cell division frequency and a
 lter the timing of cell cycle phases. AFM measurements showed that the mec
 hanical properties of cell walls of diving and expanding cells differ\, wh
 ere softening of the wall potentially aids in growth acceleration. Togethe
 r\, we show how fluctuations in environmental temperature shape cell cycle
  and growth dynamics in Arabidopsis thaliana. 
LOCATION:Online
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