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SUMMARY:Molecular bases of Shigella virulence and host immune response - P
 rofessor Benoit Marteyn from Institute of Molecular and Cellular Biology (
 IBMC)\, University of Strasbourg
DTSTART:20251106T140000Z
DTEND:20251106T150000Z
UID:TALK231124@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Shigella are pathogenic enterobacteria responsible of bacillar
 y dysentery or shigellosis. Shigella virulence relies on the expression of
  secretion systems (T3SS\, T5SS) and its ability to evolve in and adapt to
  changing microenvironments. The development of a pan-Shigella vaccine –
  which is still lacking - requires a better understanding of Shigella viru
 lence strategies\, adaptation to its host and\, more importantly\, the val
 idation of a suitable animal model of shigellosis\, to assess protection c
 onferred by candidates.\n\nI will present the most recent studies develope
 d in my team\, focusing on the importance of the pO2\, its fine tuning dur
 ing infection and subsequent modulation of Shigella secretion systems’ a
 ctivity and immune response efficacy (mainly neutrophils). I will further 
 develop the study of the interrelationship between shigellosis and vitamin
  C deficiency based on recent clinical studies and fundamental researches 
 on new shigellosis animal models.\n\n
LOCATION:Biffen Lecture theatre and Zoom
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