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SUMMARY:Small RNAs in Epigenetic Inheritance: a lesson from worms - Dr Ger
 mano Cecere from Department of Developmental and Stem Cell Biology\, Insti
 tut Pasteur\, Paris
DTSTART:20251120T140000Z
DTEND:20251120T150000Z
UID:TALK231127@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Heritable traits have traditionally been attributed to mutatio
 ns in germline DNA. However\, emerging research reveals the pivotal role o
 f epigenetic mechanisms\, including DNA methylation\, histone modification
 s\, and small RNAs in transmitting non-genetic information across generati
 ons. In our laboratory\, we explore the role of small RNAs in epigenetic i
 nheritance using the model organism Caenorhabditis elegans. In my talk\, I
  will present our findings\, emphasizing the remarkable ability of small R
 NAs to transmit traits across generations. I provide a case study of small
  RNAs that progressively reduce fertility in subsequent worm generations a
 nd delve into the underlying molecular mechanisms facilitating their trans
 generational transmission. Moreover\, I will present recent results on the
  intriguing phenomenon of small RNAs migrating from the soma to the germli
 ne\, enabling the inheritance of environmentally acquired information and 
 stress resilience.
LOCATION:Biffen Lecture theatre and Zoom
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