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SUMMARY:Remodelling the septin cytoskeleton for cytokinesis in budding yea
 st - Dr Simonetta Piatti from Centre de Recherche en Biologie Cellulaire d
 e Montpellier
DTSTART:20260312T140000Z
DTEND:20260312T150000Z
UID:TALK231142@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Septins are conserved cytoskeletal proteins essential for proc
 esses such as cell division\, spermatogenesis\, neuronal morphogenesis\, c
 iliogenesis\, infection\, and cell migration. Their dysfunction is linked 
 to neurodegeneration\, infertility\, and cancer.\nSeptins polymerize into 
 filaments and higher-order structures like rings and arcs\, which are cruc
 ial for their function. A classic example is the septin collar in budding 
 yeast—an hourglass-shaped structure at the bud neck that persists throug
 h most of the cell cycle and is essential for cytokinesis. It recruits num
 erous cytokinetic proteins\, including components of the contractile actom
 yosin ring.\nJust before cytokinesis\, the yeast septin collar undergoes a
  major remodelling into a double ring that sandwiches the actomyosin ring.
  We recently showed that this remodelling is required for actomyosin ring 
 constriction and successful cytokinesis.\nIn this seminar\, I will discuss
  our work uncovering the molecular basis of septin ring reorganisation in 
 budding yeast. Interestingly\, similar septin remodelling has been observe
 d in other fungi and in mammalian cells\, suggesting an evolutionarily con
 served process.\n
LOCATION:Biffen Lecture theatre and Zoom
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