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SUMMARY:Wires\, Reporters and Information Capsules: Cellular journalism wi
 th DNA. - Dr. Yamuna Krishnan ( National Centre for Biological Sciences\, 
 Bangalore\, India)
DTSTART:20100219T140000Z
DTEND:20100219T150000Z
UID:TALK23138@talks.cam.ac.uk
CONTACT:Erika Eiser
DESCRIPTION:DNA has attractive physicochemical characteristics such as rob
 ust thermal and hydrolytic stability. It also has desirable structural cha
 racteristics stemming from predictable and specific recognition properties
  that give rise to a highly regular helical structure which behaves as a r
 igid rod on length scales up to ~50 nm. Since these rigid rods may be weld
 ed together by complementary base-pairing\, DNA is now taking on a new asp
 ect where it is finding use as a construction element for architecture on 
 the nanoscale. This field is called structural DNA nanotechnology. I descr
 ibe approaches adopted by my lab where we demonstrate promising new self-a
 ssembly strategies that include the use of unusual forms of DNA in structu
 ral DNA nanotechnology to make molecular-scale devices. I will then go on 
 to show the application of these DNA-based molecular devices in biological
  systems.\n\nReferences:\n1.Ghodke\, H. B.\; Krishnan\, R.\; Vignesh\, K.\
 ; Kumar\, G.V.P.\; Narayana\, C.\; Krishnan\, Y.* (2007) The I-tetraplex b
 uilding block: Rational Design and Controlled Fabrication of robust 1D DNA
  Scaffolds via non-Watson Crick self assembly. Angew. Chem. Int. Ed.\, 46\
 , 2646-2649.\n2. Bhatia\, D.\, Mehtab\, S.\, Krishnan\, R.\, Indi\, S.S.\,
  Basu\, A.\, Krishnan\, Y.* (2009) Icosahedral DNA nanocapsules via modula
 r assembly. Angew. Chem. Int. Ed. accepted.\n3. Modi\, S.\; Swetha\, M. G.
 \; Goswami\, D.\; Gupta\, G. D.\; Mayor\, S.\; Krishnan\, Y.* (2009) A DNA
  Nanomachine maps spatiotemporal pH in living cells. Nature Nanotechnology
 \, 4\, 325-330.\n\n
LOCATION:Pippard Lecture Theatre\, Cavendish Laboratory
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