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SUMMARY:Comprehensive profiling of anaesthetised brain dynamics across phy
 logeny - Dr Andrea Luppi
DTSTART:20250515T140000Z
DTEND:20250515T150000Z
UID:TALK232084@talks.cam.ac.uk
CONTACT:Sarah Morgan
DESCRIPTION:Intrinsic dynamics of neuronal circuits shape information proc
 essing. Combining neuroimaging with causal perturbation offers the opportu
 nity to understand how local dynamics mediate the link between neurobiolog
 y and functional repertoire. We compile a unique dataset of multi-scale ne
 ural activity during wakefulness and anaesthetic-induced suppression of in
 formation processing encompassing human\, macaque\, marmoset\, mouse and n
 ematode. Applying massive feature extraction\, we comprehensively characte
 rise local neural dynamics across >6\,000 time-series features. Using dyna
 mics as a common space for cross-species comparison reveals a phylogenetic
 ally conserved dynamical profile of anaesthesia\, characterised by reduced
  intrinsic timescales and dampened inter-regional synchrony\, confirmed by
  computational modelling. Spatially\, this profile covaries with conserved
  transcriptional profiles of neurotransmission across human\, macaque and 
 mouse cortex. This dynamical regime is experimentally reversed in vivo by 
 deep-brain stimulation of the macaque centromedian thalamus\, restoring be
 havioural responsiveness. Altogether\, comprehensive dynamical phenotyping
  reveals that across species and scales\, anaesthetics induce spatiotempor
 al isolation of local neural activity.\n\n
LOCATION:Online
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