BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Cambridge Reading Group on Reproduction  - Peter Rugg-Gunn and Amy
  Wilkinson
DTSTART:20250611T113000Z
DTEND:20250611T133000Z
UID:TALK232468@talks.cam.ac.uk
CONTACT:120118
DESCRIPTION:*June's meeting will be led by Professor Peter Rugg-Gunn and A
 my Wilkinson\, both from the Babraham Institute. Discussing epigenetic edi
 ting of human embryos.*\n\nWhen: Wednesday 11 June\, 2025 - 12:30 to 14:30
 \n\nWhere: SB Perham Room\, Department of Biochemistry\, Sanger Building\,
  80 Tennis Ct Rd\, Cambridge CB2 1GA\n\nSign up via Doodle \nhttps://doodl
 e.com/sign-up-sheet/participate/e05ee137-8ace-4d5c-96a4-cc296e108fcc/selec
 t\n\nThe group will be led by \n\nPeter Rugg-Gunn is a Group Leader and He
 ad of Public Engagement at the Institute\, with a research interest in the
  epigenome during early human development. \n\nAmy Wilkinson began her PhD
  studies at the Babraham Institute in October 2022. She is interested in t
 he epigenetic and gene regulatory mechanisms governing human embryo develo
 pment\, and in particular\, the mechanisms controlling epiblast progressio
 n during early post-implantation stages. \n\nReadings for June\nThese two 
 papers collectively cover the key concepts that Peter and Amy would like t
 o introduce at the start of the session\nhttps://pubmed.ncbi.nlm.nih.gov/3
 6754048/\nhttps://pubmed.ncbi.nlm.nih.gov/31010926/\n\nIntroduction\nMuch 
 attention has been devoted to genetic editing of human embryos\, yet there
  has been relatively little discussion about epigenetic editing that can a
 lter the activity of genes without changing the DNA sequence. Recent techn
 ological developments have demonstrated the feasibility of epigenetic edit
 ing in human and animal embryos. In animal studies\, some of the introduce
 d epigenetic changes are long-lasting and can even be inherited in offspri
 ng.\n \nIn this session\, we will explore recent scientific developments i
 n epigenetic editing with a focus on their potential future applications a
 nd broad consequences in embryology and reproduction. These technologies r
 aise important ethical\, regulatory and societal considerations that are c
 onceptually different to those of genetic editing. We will also discuss ep
 igenetic changes that can occur during development in response to changing
  environmental exposures\, including in-vitro culture of embryos as part o
 f assisted reproduction and the in-utero environment\, with scope to explo
 re ‘epigenetic-relatedness’ versus ‘genetic-relatedness’ in the co
 ntext of surrogacy and gamete donation.
LOCATION:Department of Biochemistry - Sanger Building\, Seminar Room
END:VEVENT
END:VCALENDAR