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SUMMARY:m7G-tRNA in cancer: Molecular mechanism of resistance to METTL1 in
 hibition - Helena Santos-Rosa Ruano (Miska Lab)
DTSTART:20250523T140000Z
DTEND:20250523T150000Z
UID:TALK232600@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:N7-methylguanosine (m7G) modification of tRNAs is crucial for 
 proper folding and stability of the cellular tRNA pool. It is catalyzed by
  METTL1\, a methyltransferase overexpressed in a large proportion of malig
 nancies and a promising target for therapeutic purposes. Despite its criti
 cal role in cell proliferation\, there is a substantial number of cancers 
 insensitive to METTL1 inhibition and its genetic abrogation. Helena will p
 resent her progress towards the characterization of molecular pathways und
 erlaying METTL1 resistance in human cancer cells.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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