BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Dendrites\, Synaptic Plasticity and Hippocampal Place Fields​ - 
 Carl Ashworth\; Saeyeon Kwon
DTSTART:20250527T100000Z
DTEND:20250527T114500Z
UID:TALK232723@talks.cam.ac.uk
CONTACT:124819
DESCRIPTION:Traditional theories of Spike Time Dependent Plasticity rely o
 n near coincidence between postsynaptic and presynaptic action potentials 
 to produce plasticity. However\, recently\, the unique dendritic features 
 of the pyramidal neurons\, specifically the segregation of their dendritic
  trees into basal and apical dendrites\, have been investigated as a site 
 for branch specific plasticity - the separation of plasticity 'rules' acro
 ss dendritic locales. In this talk\, Carl will first introduce the idea of
  dendrite specific plasticity and present a recent paper by Wright et al. 
 (2025) investigating the differences between apical and basal plasticity r
 ules in L2/3 pyramidal dendrites. Saeyeon will then present the synaptic p
 lasticity mechanisms occurring in the distal tuft dendrites of hippocampal
  pyramidal neurons (O’Hare et al\, 2025).\nHippocampal pyramidal neurons
  support spatial memory by forming place fields\, which are known to arise
  through a recently described mechanism called Behavioral Timescale Synapt
 ic Plasticity (BTSP). According to BTSP\, place field formation is driven 
 by plateau potentials in distal dendrites that lead to widespread depolari
 zation across the entire dendritic arbor. However\, the relationship betwe
 en the dendritic and somatic activity in vivo\, and the cellular mechanism
 s that initiate these plateau potentials\, remain unclear. Using in vivo r
 ecording of both somatic and distal dendritic signals in a single CA1 neur
 on during a virtual reality-based spatial navigation task in mice\, the au
 thors expand on the BTSP model. They demonstrate that the timing and magni
 tude of dendritic activity predict key properties of the resultant somatic
  place fields\, and that distal tuft dendrites undergo local plasticity du
 ring place field formation.\nPapers\n"Distinct synaptic plasticity rules o
 perate across dendritic compartments in vivo during learning":https://www.
 science.org/doi/10.1126/science.ads4706\n"Distal tuft dendrites predict pr
 operties of new hippocampal place fields":https://www.cell.com/neuron/abst
 ract/S0896-6273(25)00249-1
LOCATION:CBL Seminar Room\, Engineering Department\, 4th floor Baker build
 ing
END:VEVENT
END:VCALENDAR