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SUMMARY:Sneaking in: how one bacterium mastered life inside the eukaryotic
  cytoplasm - The Salje Lab
DTSTART:20250620T140000Z
DTEND:20250620T150000Z
UID:TALK233446@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:How can a bacterium inhabit a eukaryotic cell without triggeri
 ng its destruction—or being destroyed itself? This is the central questi
 on explored by the Salje lab.\n\nOur research focuses on Orientia tsutsuga
 mushi\, an obligate intracellular bacterium that lives within the cytoplas
 m of eukaryotic host cells. This unique niche places the bacterium in clos
 e proximity to organelles and host cell processes\, offering both opportun
 ities and threats. While the cytoplasm provides access to essential nutrie
 nts\, it also exposes Orientia to cell-autonomous immune defenses evolved 
 to eliminate such invaders.\nWe use O. tsutsugamushi as a model to uncover
  how bacteria adapt to and exploit this challenging intracellular environm
 ent. Our work sheds light on the strategies used to evade host immunity an
 d establish stable\, long-term interactions with eukaryotic cells. At its 
 broadest\, this work offers insight into the evolutionary origins of eukar
 yotic life itself—echoing the ancient symbioses that gave rise to mitoch
 ondria and chloroplasts.\nIn this Biochemistry Friday seminar\, members of
  the Salje lab will present a broad overview of our ongoing research\, hig
 hlighting how one bacterium has evolved to live in remarkable intimacy wit
 h its eukaryotic host.
LOCATION:Stephenson Seminar Room\, Hopkins Building\, Downing Site
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