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SUMMARY:Structure\, Kinetics\, and the Identification of Integrated Contro
 l in Neuronal Excitability - Shimon Marom\, Technion
DTSTART:20250619T130000Z
DTEND:20250619T140000Z
UID:TALK233470@talks.cam.ac.uk
CONTACT:Fulvio Forni
DESCRIPTION:The regulation of neuronal excitability is frequently associat
 ed with structural parameters\, such as the densities of ion channel prote
 ins. This presentation introduces a complementary mode of regulation—kin
 etic-based control—in which membrane channel functional availability ref
 lects the history of activation over extended timescales\, irrespective of
  protein synthesis or degradation. This distinction between structure and 
 kinetics challenges conventional models of excitability control\, which pr
 esume separable system components and predefined targets. In physiological
  systems\, where observables\, sensors\, and actuators are integrated with
 in the same molecular substrates\, conventional decomposition-based approa
 ches fall short. I propose and demonstrate the use of closed-loop methodol
 ogical designs as a means for studying regulation of excitability under su
 ch conditions.\n\nThe seminar will be projected in LT6 (Baker Building)\, 
 Department of Engineering. You can also connect online (zoom): https://new
 nham.zoom.us/j/92544958528?pwd=YS9PcGRnbXBOcStBdStNb3E0SHN1UT09
LOCATION:LT6\, Baker Building\, Department of Engineering and online (Zoom
 )
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