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SUMMARY:Simulation of Drug Absorption in Airway Surface Liquid - Mohammad 
 Hadi Sedaghat (University of Cyprus)
DTSTART:20250619T120000Z
DTEND:20250619T130000Z
UID:TALK233482@talks.cam.ac.uk
CONTACT:Anand Srinivasan
DESCRIPTION:The effective delivery of pharmaceuticals to the respiratory t
 ract is significantly influenced by the three-dimensional covalent network
  structure of mucus\, as well as the motility of cilia within the airway s
 urface liquid (ASL). This study will examine the dissolution and absorptio
 n of respiratory drugs within the ASL\, considering the effects of mucocil
 iary clearance. A three-dimensional numerical model that characterizes muc
 us as a nonlinear viscoelastic fluid has been employed for this analysis. 
 To discretize and solve the time-dependent governing equations of fluid fl
 ow\, alongside the diffusion-convection equation for mass transfer\, a hyb
 rid immersed boundary-finite difference projection method was utilized wit
 hin the segment of the tracheal ASL on a staggered grid.
LOCATION:MR14\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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