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SUMMARY:Water: from bulk to interfaces - Prof Giancarlo Franzese\, Departm
 ent of Physics\, University of Barcelona
DTSTART:20100219T120000Z
DTEND:20100219T130000Z
UID:TALK23401@talks.cam.ac.uk
CONTACT:Dr Mark Miller
DESCRIPTION:Recently\, several experiments have investigated the relation 
 between the dynamics of the hydration water and\nthe dynamics of protein. 
 These works have generated a large amount of data whose interpretation is 
 debated. New\nexperiments measure the dynamics of water at low  temperatur
 e on the surface of proteins\, finding a qualitative change (crossover) th
 at might be related to the slowing down and stop of the protein's activity
  (protein glass transition)\, possibly relevant for the safe preservation 
 of organic material at low temperature. To better understand the experimen
 tal data several scenarios have been discussed [1]. Here\, we review these
  experiments and discuss their interpretations [2\,3] in relation with the
  anomalous properties [4] of bulk water [5] and confined water [6]. We sum
 marize the results for bulk water and investigate the thermodynamic and dy
 namic properties of supercooled water at an interface [7]. We will conside
 r also the effect of water on protein stability\, making a step in the dir
 ection of understanding\, by means of Monte Carlo simulations and theoreti
 cal calculations\, how the interplay of water cooperativity and hydrogen b
 onds interfacial strengthening affects the protein cold denaturation [8].\
 n\n\n[1] “Aspects of Physical Biology Biological Water\, Protein Solutio
 ns\, Transport and Replication”\, Book Series: Lecture Notes in Physics 
 \, Vol. 752/2008\, G. Franzese and M. Rubi (Eds.)\, Springer Berlin 2008\,
  280 p.\n\n[2] G. Franzese\, K. Stokely\, X.-Q. Chu\, P. Kumar\, M. G. Maz
 za\, S.-H. Chen\, and H. E. Stanley\, Pressure Effects\nin Supercooled Wat
 er: comparison between a 2D model of water and experiments for surface wat
 er on a protein\,\nJournal of Physics: Condensed Matter 20\, 494210 (2008)
 .\n\n[3] M. G. Mazza\, K. Stokely\, S. E. Pagnotta\, F. Bruni\, H. E. Stan
 ley\, and G. Franzese\, Two dynamic crossovers\nin protein hydration water
  and their thermodynamic interpretation\, arXiv:0907.1810v1 (2009).\n\n[4]
  P. Kumar\, G. Franzese\, and H. E. Stanley\, Predictions of Dynamic Behav
 ior under Pressure for Two Scenarios to Explain Water Anomalies\, Physical
  Review Letters 100\, 105701 (2008).\n\n[5] K. Stokely\, M. G. Mazza\, H. 
 E. Stanley\, and G. Franzese\, Effect of hydrogen bond cooperativity on th
 e\nbehavior of water\, Proceedings of the National Academy of Sciences 107
 \, 1301 (2010).\n\n[6] G. Franzese and F. de los Santos\, Dynamically Slow
  Processes in Supercooled Water Confined Between\nHydrophobic Plates\, Jou
 rnal of Physics: Condensed Matter\, Journal of Physics: Condensed Matter 2
 1\, 504107\n(2009).\n\n[7] G. Franzese\, A. Hernando-Martinez\, P. Kumar\,
  M. G. Mazza\, K. Stokely\, E. G. Strekalova\, F. de los Santos\,\nH. E. S
 tanley\, Phase Transitions and Dynamics in Bulk and Interfacial Water\, ar
 Xiv:0912.1666 (2009).\n\n[8] S. Iskrov and G. Franzese\, in preparation.
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
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