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SUMMARY:Probing the dynamics of chronic disease using stable isotopes and 
 mass spectrometry - Dr Robert Busch\, ARC Senior Research Fellow\, Departm
 ent of Medicine\, University of Cambridge
DTSTART:20100428T103000Z
DTEND:20100428T113000Z
UID:TALK23412@talks.cam.ac.uk
CONTACT:Duncan Simpson
DESCRIPTION:Chronic disease is characterised by insidious or intermittent 
 homeostatic dysregulation\, leading to persistent disruption of normal org
 an function.  Its course is often difficult to predict\, in part because u
 nderlying causal networks or disease-critical pathways are difficult to pr
 obe on relevant time scales.  One approach to this problem is to measure h
 omeostatic dysregulation of critical pathways directly to uncover incipien
 t change.  This talk will highlight the use of macromolecular biosynthetic
  labelling with heavy water to probe normal and pathologically altered hom
 eostasis.  Methodological developments and challenges will be discussed\, 
 as well as applications in the study of autoimmune diseases.
LOCATION:Seminar Room\, Centre for Physics of Medicine (PoM)
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