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SUMMARY:Mechanistic understanding-led transition metal catalyzed C-H funct
 ionalization - Professor Igor Larrosa (Department of Chemistry | Universit
 y of Manchester) 
DTSTART:20260205T140000Z
DTEND:20260205T150000Z
UID:TALK234373@talks.cam.ac.uk
CONTACT:Jasmine Mitchell
DESCRIPTION:The development of greener and more efficient synthetic method
 ologies is essential for organic chemistry to reach its full potential in 
 its application to many applied and fundamental scientific problems. Over 
 the last two decades C-H activation has emerged as a powerful tool to stre
 amline syntheses\, functionalize complex scaffolds\, while massively impro
 ving atom and step economy. However\, several challenges are still to be a
 ddressed before C-H functionalization can be widely applied: 1) the develo
 pment of mild reaction conditions with a broad scope\, including late-stag
 e functionalization\, 2) the control of the regioselectivity of C–H acti
 vation\, 3) the control of the selectivity of homo- versus cross-coupling\
 , and 4) the development of conditions that can be safely used in industry
 .  \nMechanistic understanding is a cornerstone for progress in organic ch
 emistry. In this talk I will present some of our group’s approaches in a
 pplying the knowledge derived from mechanistic studies into the design of 
 more efficient processes and of novel catalysts and catalytic systems\, su
 ch as the use of bimetallic Pd/Ag\,1 Pd/Cr2 and Au/Ag3 synergistic systems
 \, and Ru-catalysts for late stage functionalization.4\,5 Additionally\, r
 ecent developments in the application of machine learning to mechanism elu
 cidation will be discussed.6\nKeywords: Catalysis\; ruthenium catalysis\; 
 C-H activation\; machine learning\; mechanistic studies \n\nReferences\n1.
 	Chiara Colletto\, Adyasha Panigrahi\, Jaime Fernandez-Casado and Igor Lar
 rosa J. Am. Chem. Soc. 2018\, 140\, 9638-9643. \n2.	Maria Batuecas\, Junfe
 i Luo\, Ivana Gergelitsová\, Katrina Krämer\, Daniel Whitaker\, Iñigo J
 . Vitorica-Yrezabal and Igor Larrosa ACS Catal. 2019\, 9\, 5268. \n3.	Xaco
 be C. Cambeiro\, Nanna Ahlsten and Igor Larrosa J. Am. Chem. Soc. 2015\, 1
 37\, 15636. \n4.	Marco Simonetti\, Diego M. Cannas\, Xavier Just-Baringo\,
  Iñigo J. Vitorica-Yrezabal and Igor Larrosa Nature Chem. 2018\, 10\, 724
 . \n5.	Gillian McArthur\, Jamie H. Docherty\, Mishra Deepak Hareram\, Marc
 o Simonetti\, Inigo J. Vitorica-Yrezabal\, James J. Douglas and Igor Larro
 sa Nature Chem. 2024\, 16\, 1141-1150. \n6.	Jordi Bures and Igor Larrosa N
 ature 2023\, 613\, 689-695.\n\n
LOCATION:Dept. of Chemistry\, Wolfson Lecture Theatre
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