BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Multiple Routes to Metacognitive Judgments of Working Memory in th
 e Macaque Prefrontal Cortex - Xiaolu Wang
DTSTART:20250801T130000Z
DTEND:20250801T140000Z
UID:TALK234895@talks.cam.ac.uk
CONTACT:Adam Triabhall
DESCRIPTION:This week we will discuss and debate a very recent preprint by
  Ning and colleagues (2025).\n\nAbstract: "The ability to evaluate one’s
  own memory is known as metamemory. Whether metamemory is inherent to memo
 ry strength or requires additional computation in the brain remains largel
 y unknown. We investigated the metacognitive mechanism of working memory (
 WM) using two-photon calcium imaging in the prefrontal cortex of macaque m
 onkeys\, who were trained to memorize spatial sequences of varying difficu
 lties. In some trials\, after viewing the sequence\, monkeys could opt out
  of retrieval for a smaller reward\, reflecting their confidence in WM (me
 ta-WM). We discovered that PFC neurons encoded WM strength by jointly repr
 esenting the remembered locations through population coding and their asso
 ciated uncertainties. This WM strength faithfully predicted the monkeys’
  recall performance and opt-out decisions. In addition to memory strength\
 , other factors— trial history and arousal—encoded in baseline activit
 y predicted opt-out decisions\, serving as cues for meta-WM. We identified
  a code of meta-WM itself that integrated WM strength and these cues. Impo
 rtantly\, WM strength\, cues\, and meta-WM were represented in different s
 ubspaces within the same PFC population. The dynamics and geometry of PFC 
 activity implement metacognitive computations\, integrating WM strength wi
 th cues into a meta-WM signal that guides behavior" (Ning et al.\, 2025).
LOCATION:https://cam-ac-uk.zoom.us/j/92612577704?pwd=MUtqMjVQdXNmUTVIYjRkM
 G1NUW9GZz09
END:VEVENT
END:VCALENDAR