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SUMMARY:Ageing and the response to mRNA-LNP vaccination - Dr Michelle Lint
 erman\, Malaghan Institute of Medical Research\, New Zealand and Babraham 
 Institute\, Cambridge\, UK
DTSTART:20250904T100000Z
DTEND:20250904T110000Z
UID:TALK235225@talks.cam.ac.uk
CONTACT:Rachel Fellows
DESCRIPTION:Most vaccines provide protection by generating long-lived anti
 body-secreting plasma cells that block the ability of a pathogen to establ
 ish an infection. The production of vaccine-specific antibody can occur vi
 a the germinal centre response\, a specialised microenvironment that produ
 ces memory B cells and long-lived antibody secreting plasma cells. With ad
 vancing age\, the magnitude of germinal centre response declines\, resulti
 ng in decreased production of long-lived high-affinity plasma cells\, decr
 eased serum antibody levels after vaccination\, and thus impaired protecti
 on against subsequent infection.  We have established a influenza A virus 
 mRNA-LNP vaccination and efficacy testing pipeline to: 1) Understand age-r
 elated changes that contribute to impaired germinal centre formation and f
 unction. 2) Test inventions to improve vaccine effectiveness in the contex
 t of ageing.
LOCATION:Seminar Room\, Gleeson Building\, MRC Toxicology Unit\, Tennis Co
 urt Road
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