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SUMMARY:“Glia mechanisms in stress response”  - Dr. Valentina Mosienko
 \, University of Bristol
DTSTART:20250918T110000Z
DTEND:20250918T120000Z
UID:TALK235291@talks.cam.ac.uk
CONTACT:Cory Willis
DESCRIPTION:Abstract: Stress-related disorders such as anxiety and depress
 ion are the most common neuropsychiatric illnesses affecting about 8% of t
 he global population. Limited success in developing treatments to build re
 silience to stress or counteract its adverse effects is a result of our po
 or understanding of biological mechanisms of stress. In this seminar\, Dr 
 Valentina Mosienko will present their ongoing work investigating the invol
 vement of glial cells in the response to stressors encountered during earl
 y life and adulthood. She will present evidence from their preclinical res
 earch on metabolic and morphological adaptations in glial cells following 
 both acute and chronic stress exposure. Dr Mosienko will explore the mecha
 nisms by which antidepressants modulate astrocyte function\, with particul
 ar emphasis on astrocytic metabolism and the release of psychoactive molec
 ules induced by common antidepressants such as specific serotonin reuptake
  inhibitors\, rapid acting antidepressants like ketamine and psychedelics.
 \n\nBio: Dr Valentina Mosienko is an MRC Fellow and Senior Lecturer in Neu
 roscience at the University of Bristol. Her research focuses on identifyin
 g novel molecular and cellular mechanisms underlying stress response and a
 ntidepressant action\, with a particular emphasis on the role of brain gli
 al cells\, astrocytes and microglia.\n\nBefore her current appointment\, D
 r Mosienko was a Lecturer at the University of Exeter\, where she investig
 ated molecular and cellular pathways of stress response\, with a special f
 ocus on the regulatory roles of miRNAs. She completed her PhD and early po
 stdoctoral training at the Max Delbrück Center for Molecular Medicine in 
 Berlin\, where she integrated behavioural testing with molecular and pharm
 acological approaches to comprehensively study the role of the serotonergi
 c system in depression\, anxiety\, aggressive\, social and autism-like beh
 aviours. During her subsequent postdoctoral work at the University of Bris
 tol\, Dr Mosienko applied advanced molecular\, cellular\, and imaging meth
 ods to discover novel receptors involved in astrocytic lactate signalling 
 in the brain.\n\nA reminder: the talks are in-person only and a recording 
 is not available. \n\nIf you want to have a chat with the speaker\, please
  contact Cory Willis (cw739@cam.ac.uk) in advance.\n\n
LOCATION:School of Clinical Medicine - Theo Chalmers Lecture Theatre
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