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SUMMARY:Direct brain stimulation modulate physiology and behaviour in huma
 ns. - Rina Zelmann\, PhD\, Neurology at Massachusetts General Hospital &am
 p\; Harvard Medical School
DTSTART:20250826T150000Z
DTEND:20250826T163000Z
UID:TALK235318@talks.cam.ac.uk
CONTACT:Adelaide Schiemer
DESCRIPTION:Direct brain electrical brain stimulation offers a causal wind
 ow on human brain function and a route to therapy. This talk contrasts ope
 n-loop perturbation\, single pulses and short trains used to map effective
  connectivity and state dependence across wake\, sleep and anaesthesia\, w
 ith closed-loop paradigms that detect neural features in intracranial EEG 
 in real time to trigger stimulation. I’ll show how closed-loop experimen
 ts can adjust stimulation based on estimated cognitive state\, producing r
 apid changes in cortical dynamics and measurable effects on behaviour duri
 ng ongoing tasks. I’ll also discuss high-frequency oscillations and ripp
 les as candidate biomarkers for targeting\, and outline opportunities and 
 limits for translating these methods to precision neuromodulation in human
 s.\n\nThe Host for this talk is Tristan Bekinschtein\, tb419@cam.ac.uk.
LOCATION:Ground Floor Lecture Theatre\, Department of  Psychology
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