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SUMMARY:Adventures in Imaging Metallomics: illuminating metal behavior in 
 cancer and beyond - Cinzia Imberti - Kings College London
DTSTART:20250918T140000Z
DTEND:20250918T150000Z
UID:TALK235558@talks.cam.ac.uk
CONTACT:Sara Seddon
DESCRIPTION:More than 75% of all known chemical elements are metals\, high
 lighting their fundamental role in nature and life. Among them\, endogenou
 s metal ions play crucial roles in virtually all biological processes\, se
 rving as signaling molecules  or as structural and catalytic cofactors for
  proteins. Exogenous metals also interact with biological systems\, a feat
 ure harnessed in the development of metal-based drugs\, but also evident i
 n the detrimental effects of environmental metal contaminants on our healt
 h. Despite their critical importance\, the biological behavior of metals r
 emains poorly understood\, complicated by their intricate speciation and l
 ow concentrations in biological systems.\n\nRecent advances in metal-speci
 fic imaging techniques such as laser ablation inductively-coupled plasma m
 ass spectrometry (LA-ICP-MS) now make it possible to map the spatial distr
 ibution of metals in cells and tissues. At the same time\, the growing ava
 ilability of radiometals (52Mn\, 62Zn\, 64Cu\, 195mPt\, 203Pb) with emissi
 on properties suitable for radionuclide imaging\, provides powerful tools 
 to measure dynamic metal fluxes in vivo.\n\nIn this talk\, I will discuss 
 how we are integrating these complementary techniques — an approach we r
 efer to as imaging metallomics — to illuminate the biological behavior o
 f endogenous metals and metal-based therapeutics\, with a particular focus
  on cancer.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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