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SUMMARY:The SEISMIC facility for spatially resolved single and sub-cellula
 r omics - Melanie Bailey - Kings College London
DTSTART:20251127T150000Z
DTEND:20251127T160000Z
UID:TALK235570@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:The SEISMIC facility is a new BBSRC national facility that is 
 advancing single cell and sub-cellular measurements.  We use capillary sam
 pling to sample live cells or sub-cellular compartments under microscope o
 bservation\, and measure them using mass spectrometry.  We will also show 
 how lipid and metabolite profiles of single cancer cells respond to drug\,
  infection and radiation treatment [1-5].  We will present new work showin
 g sub-cellular metallomics and proteomics. Finally\, the talk will describ
 e a new approach to multimodal imaging using both keV and MeV ion beams\, 
 providing the opportunity to co-localise metals with biomolecules at sub-c
 ellular spatial resolution.\n\n \n\n \n\nBio\n\nMelanie Bailey is Professo
 r of Physical Sciences of Life at Kings College London and Professor of An
 alytical Science at the University of Surrey.  She is Director of SEISMIC\
 , a new BBSRC national facility for spatially resolved single and sub-cell
 ular “omics” and is Principal Investigator for an EPSRC funded project
  to bring new instrumentation for multimodal imaging at the UK National Io
 n Beam Centre for correlative imaging of metals and other omics markers. S
 he is a member of the international advisory board for the Ion Beam Analys
 is conference series\, International Nuclear Microprobe conference series 
 and the Bragg Institute. She is a Trustee of the Analytical Chemistry Trus
 t Fund and recently obtained a Guiness World Record as “Fastest Marathon
  Dressed as a Cell” to raise awareness and funding for analytical scienc
 e. She is Editor in Chief of the Royal Society of Chemistry’s longest ru
 nning journal “Analyst”.\n\n \n\n[1] Lewis\, H.-M.\, et al. (2023). "N
 anocapillary sampling coupled to liquid chromatography mass spectrometry d
 elivers single cell drug measurement and lipid fingerprints." Analyst 148(
 5): 1041-1049.\n\n[2] Saunders\, K. D.\, et al. (2023). "Single-Cell Lipid
 omics Using Analytical Flow LC-MS Characterizes the Response to Chemothera
 py in Cultured Pancreatic Cancer Cells." Analytical Chemistry 95(39): 1472
 7-14735.\n\n[3] von Gerichten\, J.\, et al. (2024). "Single-Cell Untargete
 d Lipidomics Using Liquid Chromatography and Data-Dependent Acquisition af
 ter Live Cell Selection." Analytical Chemistry 96(18): 6922-6929.\n\n[4] K
 ontiza\, A.\, et al. (2024). "Single-Cell Lipidomics: An Automated and Acc
 essible Microfluidic Workflow Validated by Capillary Sampling." Analytical
  Chemistry 96(44): 17594-17601.\n\n[5] Saunders et al (2025) \, Analytical
  Chemistry 10.1021/acs.analchem.5c02010\n\n
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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