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SUMMARY:Interaction dynamics of disordered proteins: From disordered compl
 exes to biomolecular phase separation - Ben Schuler Professor of Molecular
  Biophysics\, University of Zurich
DTSTART:20250905T130000Z
DTEND:20250905T140000Z
UID:TALK235609@talks.cam.ac.uk
CONTACT:Ella de Csillery
DESCRIPTION:Many proteins perform essential functions without being folded
 . Quantifying the highly dynamic and conformationally diverse ensembles of
  these intrinsically disordered proteins (IDPs) and their interaction mech
 anisms is an important aspect of understanding their functions. A remarkab
 le example are highly charged IDPs\, which can form high-affinity interact
 ions but retain their disorder in the complexes. I will illustrate how adv
 anced single-molecule spectroscopy combined with molecular simulations and
  other biophysical methods can be used to probe the dynamics and interacti
 ons of such disordered systems\, which range from 1:1 dimers and oligomers
  to phase-separated droplets.
LOCATION:Yusuf Hamied Department of Chemistry\, Pfizer Lecture Theatre
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