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SUMMARY:BSU Seminar: &quot\;Predictive Polygenic Scores: Considerations an
 d an Example&quot\; - Allison Meisner\, Assistant Professor\, Fred Hutchin
 son Cancer Center
DTSTART:20250911T120000Z
DTEND:20250911T130000Z
UID:TALK235612@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:There is growing interest in using scores\, including polygeni
 c scores\, to guide individualized treatment selection as well as to avoid
  treatment toxicity. Many efforts have focused on prognostic scores for th
 is purpose\, though predictive scores are a compelling alternative. In thi
 s seminar\, I will define and compare these two approaches and the implica
 tions of using each. Furthermore\, comparisons of these two scoring modali
 ties in real trial data are lacking. Given previous work that found a modi
 fication of the effect of finasteride on prostate cancer risk by genetic m
 arkers\, it is important to understand how prognostic and predictive polyg
 enic scores might be used to guide use of finasteride. I utilized data fr
 om the Prostate Cancer Prevention Trial (PCPT)\, a large randomized study 
 of finasteride for the prevention of prostate cancer\, to compare the util
 ity of these scores for guiding finasteride use. This analysis of nearly 8
 \,000 PCPT participants found greater utility for the predictive scores. T
 hese results provide insights into the relationship between finasteride an
 d prostate cancer risk\, as well as an illustration of the potential benef
 its and challenges of developing polygenic scores for intervention selecti
 on. 
LOCATION:Large Downstairs Teaching Room\, East Forvie Building\, Forvie Si
 te Robinson Way Cambridge CB2 0SR.
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