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SUMMARY:Rapid evolution of the RNA polymerase 3 transcriptome in mammals -
  Claudia Kutter (CRI)
DTSTART:20100319T130000Z
DTEND:20100319T133000Z
UID:TALK23617@talks.cam.ac.uk
CONTACT:15560
DESCRIPTION:Transfer ribonucleic acids (tRNAs) are the crucial molecular a
 daptors that convert genetic information into proteins in every living org
 anism. We combined computational and experimental approaches to characteri
 ze the identity\, conservation\, and divergence of the active tRNA loci tr
 anscribed by RNA polymerase 3 in livers of five mammalian species. A core 
 set of tRNA loci was active in all mammals that together encompassed all k
 nown 46 tRNA isoacceptor classes. We further confirmed the transcription o
 f tRNAs by sequencing the actual tRNAs. Unexpectedly\, we further discover
 ed that specific tRNAs give rise to a large number of small RNA that show 
 hallmarks of a highly specific\, nucleolytic processing mechanism. Since t
 hese tRNA derived small RNAs originate from distinct loci in each species 
 the regulatory roles of these small RNAs play must be highly species-speci
 fic.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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