BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:New actin nanoprobes distinguish between apical and lateral cortic
 al actin in polarised epithelial cells. -  Dmitry Nashchekin
DTSTART:20251015T150000Z
DTEND:20251015T163000Z
UID:TALK236398@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Over the years\, significant progress has been made in underst
 anding the nature of membrane-associated polarity factors and the molecula
 r mechanisms driving the formation of cortical polarity domains during epi
 thelial cell polarisation. However\, how cortical apical-basal polarity tr
 anslates into intracellular asymmetries remains largely unclear. In partic
 ular\, the formation of apical-to-basal-oriented non-centrosomal microtubu
 le arrays\, which maintain epithelial cell polarity by directing the asymm
 etric distribution of vesicles and proteins\, is not well understood.\nBas
 ed on the Drosophila spectraplakin actin-binding domain\, we designed new 
 actin-binding probes that selectively recognised the apical and lateral ac
 tin cortices in epithelial cells. Our experiments showed that the actin co
 rtex in polarised epithelial cells is more heterogeneous than previously a
 ssumed with different types of actin networks present in the apical and la
 teral cortical domains. These specialised networks may selectively recruit
  distinct subsets of actin-binding proteins and play a crucial role in tra
 nslating the asymmetric distribution of cortical polarity factors into the
  polarised organisation of microtubules and membrane trafficking. 
LOCATION:in person at Gurdon Institute
END:VEVENT
END:VCALENDAR